Abstract
Olfactory bulb responses to paired-pulse stimulation of the lateral olfactory tract were examined in urethane-anesthetized rats, aged 5 days to adult. Brief inter-pulse intervals resulted in a depression of test responses at all ages. The magnitude of this depression decreased dramatically between postnatal days 19 and 20 to approach adult levels. Longer inter-pulse intervals resulted in a facilitation of test response amplitude in adult animals. This facilitation was evident at adult levels by postnatal day 10. These results suggest that both inhibitory and facilitatory synaptic mechanisms appear early in the course of rat olfactory bulb development. Furthermore, presumed granule cell-mediated inhibition is present at unusually high levels in the developing bulb, decreasing sharply between days 19 and 20.
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