Abstract
AbstractWhen small doses of allogeneic spleen cells are injected into rabbits or mice made tolerant to either human or bovine serum albumin, about half the treated animals will escape from tolerance. The effective doses in rabbits are 2 x 106 to 5 x 106 cells per animal and in mice 104 to 106 cells per animal. Larger doses, around 25 x 106 cells in rabbits, are ineffective.It is suggested that by transferring sufficiently small doses of allogeneic cells the threshold of the recipient's rejection mechanism can be circumvented.
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