Abstract
Background Brd4 (bromodomain-containing protein 4) is an important epigenetic reader that plays a crucial role in cellular proliferation and cell cycle progression. Several recent studies have identified Brd4 as a critical therapeutic target in a number of different cancers. Brd4 is also an important target of several oncogenic viruses and the translocation t (15;19) that accounts for a highly aggressive carcinoma. The t(15;19) translocation results in the novel in-frame fusion of the Brd4 N-terminal component with almost the entire sequence of Nut (Nuclear protein in testis) molecule, leading to the formation of a novel fusion oncogene, Brd4-Nut. The mechanism by which the Brd4-Nut fusion product contributes to oncogenesis remains to be clearly defined.
Highlights
Abrogation of Brd4 cellular function contributes to the oncogenic mechanisms of translocation t(15;19)-associated carcinoma
Brd4 is an important epigenetic reader that plays a crucial role in cellular proliferation and cell cycle progression
Using the bimolecular fluorescence complementation (BiFC) technology, we demonstrated that Brd4 molecules interact intermolecularly on chromatin to provide a molecular scaffold for maintaining nucleosomes in a properly organized chromatin conformation
Summary
Brd4 (bromodomain-containing protein 4) is an important epigenetic reader that plays a crucial role in cellular proliferation and cell cycle progression. Abrogation of Brd4 cellular function contributes to the oncogenic mechanisms of translocation t(15;19)-associated carcinoma Background Brd4 (bromodomain-containing protein 4) is an important epigenetic reader that plays a crucial role in cellular proliferation and cell cycle progression.
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