Abrogation by Curcumin on Testicular Toxicity Induced by Cisplatin in Rats

Abstract

Cisplatin is one of the most effective and widely-used antineoplastic agents for the treatment of testicular germ cell tumors. The present study was conducted to examine the possible modifying effects of curcumin against testicular toxicity induced by cisplatin in male rats. 60 male albino rats were equally divided into six groups; the first and second groups were the control and curcumin treated group respectively while the 3rd group was cisplatin treated group; the 4th and 5th groups were co- and post treated cisplatin rat with curcumin respectively and the 6th group was self treated cisplatin rat group. Many side effects were observed in animals injected with cisplatin such as loosing of body weight, loss of activity, weakness, yellowish body hair. A significant decrease in the body and testicular weights,, sperm counts, sperm motility, plasma testosterone, luteinizing hormone reduced glutathione, total antioxidant capacity, and total protein levels in cisplatin and cisplatin self treated groups when compared with the control group. On the other hand; a significant increase in the MDA and NO in cisplatin and cisplatin self treated groups when compared with the control group. sperm count and sperm motility, GSH and TAC exhibited significant increased in cisplatin treated with curcumin when compared with cisplatin groups, moreover, sperm abnormality, MDA, NO and total protein exhibited significant decrease in cisplatin treated groups with curcumin when compared with cisplatin groups. A significant decrease in sperm abnormality, MDA, NO and total protein and a significant increase in GSH and TAC in Co-treated group when compared with post treated cisplatin with curcumin. Our recommendation, administration of curcumin caused ameliorative effect against cisplatin-induced testicular toxicity.