Abstract
Abrikossoff’s tumors can become a difficult diagnostic challenge for the physicians because of their clinical, mammographical, and sonographical aspects, mimicking a primary breast carcinoma. We report of a healthy 31-year-old Bulgarian woman who presented to us for an assessment of a firm and thick palpable mass in the inferior medial quadrant of the left breast several months after giving birth. The ultrasonography (US) revealed a hypoechoic, nonhomogeneous solid mass (21/17 mm) with axillary lymphadenopathy. Wide local excision of the lesion was done. The final histologic evaluation confirmed the diagnose – benign granular cell tumor (GCT) of the breast with non-tumoral margins. At the one year follow up there was no evidence of a recurrent lesion. GCT is one of the rarest tumors of the breast. Correct recognition of granular cell tumor is crucial for an adequate therapeutical approach.
Highlights
Granular cell myoblastoma was originally described by Alexei Abrikossoff in 1926, assuming a myogenic origin [1]
Granular cell tumors (GCTs) are rare soft-tissue neoplasms probably derived from Schwann cells [6]
Multiple granular cell tumors may be seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene [7]
Summary
Granular cell myoblastoma was originally described by Alexei Abrikossoff in 1926, assuming a myogenic origin [1]. Today it is considered that these type of neoplasms originate from putative Schwann cells based on their immunophenotypic and ultrastructural characteristics [2]. Granular cell tumors (GCT) are usually benign but less than 2% of them show the tendency to become a malignant version, associated with a poor prognosis [3]. When located in the breast, Abrikossoff’s tumors can become a serious diagnostic challenge for the physicians because of their clinical, mammographical, and sonographical aspects, mimicking a primary breast carcinoma [4]. The histopathological and immunohistochemical result gives the definitive diagnose. The treatment of GCT should be wide local excision with clear margins of healthy breast tissue [5]
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