Above and Beyond Number of Illnesses: A Two-Sample Replication of Current Approaches to Depressive Symptoms in Multimorbidity

Abstract

ABSTRACT Objectives To expand current models of depressive symptoms in older adults with multimorbidity (MM) beyond the number of illnesses as a predictor of worsened mental health. Methods Two-sample replication study of adults ≥62 years old with ≥ two chronic illnesses, who completed validated questionnaires assessing depressive symptoms, and disease- and treatment-related stressors. Data were analyzed using hierarchical linear regression. Results The model of cumulative number of illnesses was worse at explaining variance in depressive symptoms (Sample 1 R2  = .035; Sample 2 R2  = .029), compared to models including disease- and treatment-related stressors (Sample 1 R2  = .37; Sample 2 R2  = .47). Disease-related stressors were the strongest factor associated with depressive symptoms, specifically, poor subjective cognitive function (Sample 1: b = -.202, p = .013; Sample 2: b = -.288, p < .001) and greater somatic symptoms (b = .455, p < .001; Sample 2: b = .355, p < .001). Conclusions Using the number of illnesses to understand depressive symptoms in MM is a limited approach. Models that move beyond descriptive relationships between MM and depressive symptoms are needed. Clinical implications Providers should consider the role of somatic symptom management in patients with MM and depressive symptoms.