About the interrelationship between the gastric acidity by the stimulation of gastrin and the pathologic tissues (II)

Abstract

1) The cases with the normal fundic area have slight inflammation in the pyloric area and indicate normoacidity. 2) The superficial gastritis is without any atrophy in the fundic area with 53.6% of our patients with severe atrophy of the antrum-gastritis and, these cases show anacidity, hypacidity normo-acidity and hyperacidity. 3) 28.5% of our patients with extremely severe atrophy of the Antrum-gastritis have very severe atrophy in the fundic area, too, and present anacidity and hypacidity. 4) N-II and N-III show severe atrophy in the pyloric area and indicate hypacidity. From these facts, we see that both the patients without any inflammation in either antrum or fundus and those cases with severe inflammation indicate a close interrelationship with the gastric acidity, but that 53.6% of the cases having severe atrophy of the antrum-gastritis present no remarkable tendency. Consequently, our conclusion will be that, as M. C. Guigan said, if the cells secreting gastrin exist in the mucous membrane of the antrum, the gastric acidity is dominated by the degree of the inflammation in the fundus-gastritis without regard to the condition of the inflammation of the antrum-gastritis, as long as the pyloric area gives the strongest stimulation exogenously in spite of the reduction of the secretion of gastrin by severe atrophy.