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Abstract

Next article FreeAbout the CoverPDFPDF PLUSFull Text Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinked InRedditEmailQR Code SectionsMoreCoverThe image on the cover is a Ptychodera flava hemichordate in the Krohn stage of larval development. This larva will undergo a dramatic metamorphosis to become a tripartite, marine acorn worm. The nuclei are stained with DAPI (blue), and dividing cells are stained with the marker EdU (green). The ciliary bands that wrap around the animal are densely populated with cells and can be seen as rich blue, wavy lines, a prominent character of the Krohn stage. Significant cell proliferation is also apparent throughout the ciliary bands and C-shaped collar and trunk coeloms sprouting from the midgut region.Ptychodera flava larvae undergo a long larval stage and can drift in the plankton for approximately a year before undergoing metamorphosis. The larval body must develop though several progressive developmental stages before becoming competent for metamorphosis.On pages 152–164, S. M. Luttrell, Y.-H. Su, and B. J. Swalla show that within two to four weeks after bisection through the sagittal, coronal, or axial planes, P. flava larvae completely regenerate all structures. Regeneration fidelity is not equal between the different larval halves and between the different bisection planes. This suggests that an unknown stem cell niche may be required for complete regeneration. EdU staining was performed to determine whether dividing cells are bona fide stem cells. While adult P. flava acorn worms are known to regenerate all tissues, this report provides new knowledge about regeneration in P. flava during the larval stage of development.Credits: Photo, Shawn Luttrell, University of Washington. Cover design, Jeannie Harrell, University of Chicago Press. Next article DetailsFiguresReferencesCited by The Biological Bulletin Volume 234, Number 3June 2018 Published in association with the Marine Biological Laboratory Article DOIhttps://doi.org/10.1086/699540 © 2018 by The University of Chicago. All rights reserved.PDF download Crossref reports no articles citing this article.