Abstract
Previous studies have shown that gonadotropin response to I/V bolus injection of GnRH differs in prepubertal (PPP) and pubertal patients (PP). In the PPP patients GnRH response is minimal, with the LH/FSH ratio being less than one. In contrast, the PP patient demonstrates a marked response in LH secretion with the LH/FSH ratio being greater than one. We studied a group of 12 girls, aged 6 to 8 years, designated as Aborted Puberty (AB). They all presented with signs of precocious puberty (breast & pubic hair development) but differed from true precocious puberty in that their early pubertal development spontaneously regressed. These AB patients responded differently to GnRH than expected, as seen in the table below. They demonstrated a greater rise in both FSH and LH than the PPP patients. In contrast to the PP patients their LH/FSH ratio is less than one. We submit to have discovered a new variant of normal pubertal development, termed “Aborted Puberty”, which is different from all other pubertal states based on its gonadotropin response to GnRH stimulation.
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