ABO blood types associated with the risk of venous thromboembolism in Han Chinese people: A hospital-based study of 200,000 patients

Xuefeng Sun,Wei Wu,Min Peng,Juhong Shi,Jun Feng

doi:10.1038/srep42925

Abstract

ABO blood types are putatively associated with the risk of venous thromboembolism (VTE), but it is not proved in Chinese people. A large population of Han Chinese patients discharged from Peking Union Medical College Hospital between January 2010 and June 2016 were retrospectively analyzed in a case-control study. A total of 1412 VTE patients were identified from 200,660 discharged Han Chinese patients, including 600 patients with deep vein thrombosis (DVT), 441 patients with pulmonary embolism, and 371 patients with both DVT and pulmonary embolism. The prevalence of non-O blood type was weakly but statistically higher in VTE patients compared with 199,248 non-VTE patients, with an odds ratio (OR) of 1.362 (95% confidence interval [CI], 1.205–1.540). Subgroup analysis showed that the OR for non-O blood type was still increased. It was greater in pre-hospital VTE (OR = 1.464) than that in hospital-acquired VTE (OR = 1.224), and greater in unprovoked VTE (OR = 1.859) than that in provoked VTE (OR = 1.227). The OR for non-O blood type decreased with age in subgroup analysis. These results suggest a weak but statistically significant correlation between non-O blood type and risk of VTE in Han Chinese people.

Highlights

The genetic profile for thrombosis of Chinese people differs from that of Caucasians
We investigated a link between ABO blood types and VTE in a Han Chinese population by referencing a database of more than 200,000 patients who had been discharged from a tertiary hospital in China
In subgroups with pre-hospital and hospital-acquired VTE cases, and with unprovoked and provoked VTE cases, when the mean ages were compared, a decreased odds ratio (OR) was noted in the subgroup with an older mean age. In this case-control study, we analyzed the distribution of ABO blood types in a large-scale database containing more than 200,000 discharged Han Chinese patients, and found that the prevalence of non-O blood type was statistically higher in patients with VTE compared with non-VTE patients

Summary

Introduction

The genetic profile for thrombosis of Chinese people differs from that of Caucasians. Factor V Leiden and prothrombin G20210A are major risk factors of VTE in Caucasians, but are not detected in Chinese populations[8]. It should be investigated whether ABO blood types are associated with the risk of VTE in Chinese people. We investigated a link between ABO blood types and VTE in a Han Chinese population by referencing a database of more than 200,000 patients who had been discharged from a tertiary hospital in China

Methods

Results

Conclusion