Abstract
Ovarian reserve reflects both the quantity and quality of oocytes available for procreation, and is affected by many known and unknown factors. ABO blood type is related to a number of infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve. Here, we explored the relationship between ABO blood type and ovarian reserve in Chinese women with subfertility. Day-3 serum follicle-stimulating hormone (FSH) levels and blood type were examined in 14,875 women who underwent IVF or ICSI treatment. Blood type proportions in the patient population were as follows: 30.98% type A, 24.54% type B, 7.57% type AB, and 36.91% type O. A higher percentage of women with diminished ovarian reserve (DOR) were blood type O, while a lower percentage had the B antigen (B and AB). Multiple logistic regression analysis revealed that blood type O was associated with a greater risk of DOR than blood type B and B antigen-positive types. By contrast, the B antigen (B and AB) was associated with a lower incidence of DOR than blood type O. These results suggest that blood type O is a risk factor for DOR while the B antigen (blood type B or AB) is a protective factor for ovarian reserve in Chinese women with subfertility. Further studies are needed to confirm this effect and identify the underlying mechanisms.
Highlights
Ovarian reserve, a measure that takes into account the quantity and quality of remaining oocytes, is indicative of a woman’s reproductive potential [1]
Clinical characteristics and blood type proportions according to ovarian reserve status As shown in Table 2, participants were divided into two groups based on follicle stimulating hormone (FSH) concentration
Our analysis indicated that ABO blood type was closely associated with ovarian reserve in these patients; those with blood type O had an increased risk of diminished ovarian reserve (DOR), while the B antigen was associated with a decreased incidence of DOR
Summary
A measure that takes into account the quantity and quality of remaining oocytes, is indicative of a woman’s reproductive potential [1]. Recent studies have examined the relationship between blood type and ovarian reserve, but have obtained contradictory results [8,9,10,11,12]. Among these studies, two indicated that blood type is associated with ovarian reserve, the directions of the relationships were inconsistent [8, 9]. The other three studies found no relationship between blood type and ovarian reserve [1012]. We collected and analyzed data from our center to investigate the association between blood type and ovarian reserve
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