Abstract
A review of blood-group data in 260 cases revealed that the risk of choriocarcinoma developing after any form of pregnancy is critically related to the ABO groups of both the woman and her husband. Women of group A married to males of group O seem to have the highest risk, whereas women of group A married to males of group A have the lowest: the relative risk of these two groups was found to be 10.4/1. The spontaneous regression of trophoblast after evacuation of hydatidiform mole happened most commonly in women mated to males of their own ABO phenotype. Group-AB patients tend to have rapidly progressive tumours which do not respond well to chemotherapy. The data indicate that genetic factors strongly affect the development of choriocarcinoma. These effects are possibly mediated immunologically, but the observations do not appear to conform with current concepts of tumour/host and materno/fetal interaction.
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