Abstract
Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
Highlights
Infection by Helicobacter pylori is linked to gastroduodenal disease and seems to be dependent on genetic factors of the host and virulence factors presented by this microorganism [1,2,3]
These results suggest that H. pylori cytotoxin associated antigen A (cagA) infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers
Previous reports that suggesting that infections by the H. pylori bacillus may be influenced by genetic traits of the host prompted us to test the hypothesis of an association between the ABO histo-blood groups and cagA infections
Summary
Infection by Helicobacter pylori is linked to gastroduodenal disease and seems to be dependent on genetic factors of the host and virulence factors presented by this microorganism [1,2,3]. Previous reports have shown that H. pylori strains that have the cagA gene infect Brazilian patients suffering from various gastroduodenal diseases [6,7,8]. Studies correlating infection by epidemiologically important microorganisms such as H. pylori may provide relevant biological and clinical contributions by identifying genetic risk factors of the host and the stages of virulence and pathogenesis of the infectious agent [9]. The aim of this study was to investigate the association between the ABO histo-blood groups and H. pylori cagA infection
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