Abstract
This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We searched the Pubmed database on the relationship between ABO blood groups and gastric cancer risk for meta-analysis. In our case-control study, the risk of gastric cancer in blood group A was significantly higher than that in non-A groups (O, B and AB) (odd ratio, OR1.34; 95% confidential interval, CI 1.25–1.44). Compared with non-O groups (A, B and AB), individuals with blood group O demonstrated a reduced risk of gastric cancer (OR = 0.80; 95% CI 0.72–0.88). The proportion of H. pylori infection in blood group A individuals was significantly higher than that in non-A blood groups (OR = 1.42; 95% CI 1.05–1.93). We further combined our data with the published data of others, and crossreferenced the risk of gastric cancer with the blood type, finding consistent evidence that gastric cancer risk in the blood A group was higher than that in the non-A groups (OR = 1.11; 95% CI 1.07–1.15), and that blood type O individuals were consistently shown gastric cancer risk reduction (OR = 0.91; 95% CI 0.89–0.94). Our study concluded that there was a slightly increased risk of gastric cancer in blood group A individuals, and people with blood type A are more prone to be infected by H. pylori than other ABO blood type individuals, whereas, a slightly decreased risk of gastric cancer was identified in blood type O individuals.
Highlights
Gastric cancer is the second most common cause of cancer death worldwide [1,2]
In comparing the gastric cancer group with the healthy controls, it becomes evident that the risk of gastric cancer in blood groups A was significantly higher than that in non-A groups (OR = 1.34, 95% confidence intervals (CI) 1.25–1.44)
The individuals with blood group O showed a significant reduced risk of gastric cancer (OR = 0.80, 95% CI 0.72–0.88)
Summary
Gastric cancer is the second most common cause of cancer death worldwide [1,2]. About one million patients are newly diagnosed with gastric cancer each year, with 700,000 deaths each year [1].It is known that gastric cancer can be caused by the interaction between environmental factors and genetic variations [3,4,5]. Gastric cancer is the second most common cause of cancer death worldwide [1,2]. About one million patients are newly diagnosed with gastric cancer each year, with 700,000 deaths each year [1]. It is known that gastric cancer can be caused by the interaction between environmental factors and genetic variations [3,4,5]. Helicobacter pylori (H. pylori) infection plays an important role in the development of gastric cancer. Only a small proportion of H. pylori carriers develop gastric cancers. Such clinical diversity indicates that there are likely to be other factors in gastric carcinogenesis, including genetic susceptibility of the host [6,7,8]
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