Abstract
SummaryEarlier studies of the distribution of blood groups in trophoblastic disease have suggested a shift in ABO group from O towards A, B and AB, and have invoked failure of maternal immunological defence as a possible factor in development of choriocarcinoma. The present study compares the ABO blood group distribution of the normal Singapore population with that in 351 cases of hydatidiform moles and 87 cases of choriocarcinoma. There was no significant shift in the ABO blood group distribution in patients with hydatidiform mole. However, there was a significant increase in the incidence of blood group A and a significant decrease of blood group B in patients with choriocarcinoma; this is not due to race. There was a higher mortality of choriocarcinoma in group AB. There was no definite relationship between ABO blood group and the amount of chemotherapy required to produce remission. An enzyme deficiency could possibly account for the predominance of blood group A in patients with choriocarcinoma.
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