Abstract
Objective To evaluate the relationship between ABO blood group system and the risk of gastric cancer by casecontrol study and meta-analysis. Methods In our case-control study,930 cases of gastric cancer were enrolled and 8 426 cases with other diseases were taken as controls from Changhai Hospital. PubMed were searched with unlimited initial time and the cutoff time on December 31,2013; and our case-control study was also included. Two reviewers evaluated the quality of the included case-control studies by Newcastle-Ottawa scale( NOS) and extracted the data independently. The meta-analysis was performed by Meta-Analyst 3. 13 software. Results The case-control study showed that blood type A might be a risk factor of gastric cancer( OR = 1. 58; 95% CI: 1. 37-1. 81). The results of meta-analysis showed that the risk of gastric cancer of blood group A was significantly higher than that of non-A groups( OR = 1. 28; 95% CI: 1. 01-1. 62); meanwhile,blood group O demonstrated a lower risk of gastric cancer compared with non-O groups( OR = 0. 84; 95% CI: 0. 73-0. 96); subgroup analysis found differences between home population and foreign population. Conclusion ABO blood group system is associated with the risk of gastric cancer,and type A might be one of the risk factors of gastric cancer.
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