Abstract
Ovarian reserve reflects a woman's fertility potential. The ABO blood group system is a very stable genetic marker. Although many recent studies have explored the relationship between ABO blood group and ovarian reserve, a consensus has not yet been reached. This paper is the first meta-analysis and systematic review of the relationship between ABO blood type and ovarian reserve. We analyzed seven cross-sectional studies evaluating follicle stimulating hormone (FSH) or anti-Mullerian hormone (AMH) levels in 55,113 participants to determine ovarian reserve. This study found no relationship between ABO blood type and ovarian reserve when FSH was used as an indicator of ovarian reserve (A vs non-A:OR=1.03, 95% CI:0.96-1.11; B vs non-B: OR=0.98, 95% CI:0.75-1.29; AB vs non-AB:OR=0.96, 95% CI:0.71-1.30; O vs non-O:OR=1.03, 95%CI:0.74-1.43).There was also no relationship between ABO blood type and ovarian reserve when AMH was used as an indicator (A vs non-A:OR=0.89, 95% CI:0.76-1.03; B vs non-B:OR=1.02, 95% CI:0.80-1.30; AB vs non-AB:OR=1.14, 95% CI:0.80-1.64, O vs non-O:OR=1.07, 95% CI:0.86-1.34). Overall, the current study found no relationship between ABO blood group and ovarian reserve. However, additional rigorous, high-quality and multi-indicator studies with large sample sizes are required for further verification.
Highlights
Ovarian reserve refers to reproductive potential as a function of the number and quality of remaining oocytes [1]
decreased ovarian reserve (DOR) gradually evolves into premature ovarian failure (POF), which contributes to osteoporosis, cardiovascular disease and other related health issues [6].These conditions have serious impacts on a woman’s reproductive health and quality of life and place a certain burden on the family and society
Recent studies have focused on age, antral follicle count(AFC), and hormones, follicle stimulating hormone(FSH) and antiMullerian hormone(AMH), all of which can serve as indicators of ovarian reserve [7]
Summary
Ovarian reserve refers to reproductive potential as a function of the number and quality of remaining oocytes [1]. Changes in the social environment, lifestyle and prolonged female reproductive years have led to gradual increases in female infertility [2, 3]. Approximately 10% of infertile women have decreased ovarian reserve (DOR) [4], causing altered hormone levels that largely clinically manifest as peri-menopausal symptoms, such as hot flashes, sweating, anxiety, irritability, insomnia and other symptoms [5]. The method used for detection is simple, economical, highly reproducible, and widely applied in clinical practice [8].The sensitivity and specificity of AMH in predicting ovarian response are high [9], and this hormone shows no significant fluctuations during the menstrual cycle [10]. AMH measurement is convenient and rapid, with great potential in clinical application
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