Abstract
IntroductionChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, sometimes including the central nervous system. The aim of the study was the assessment of the prevalence of central sensory impairment and its reliance on peripheral nerve damage in patients with CIDP.Material and methodsMultimodal (visual—VEP, brainstem auditory—BAEP, somatosensory—SEP) evoked potentials (EPs) were studied in 24 patients diagnosed with CIDP. The results were compared with neurographic parameters of sensory responses. The control group consisted of 35 healthy volunteers selected with respect to age and sex.ResultsMean latency of most components of EP were considerably prolonged in patients compared with the control group. There were no correlations between the P100 VEP latency and the peripheral sensory parameters. Statistically significant negative correlations were obtained between BAEP and SEP responses and the amplitude and sensory conduction velocity of peripheral nerves. The inter-latencies were also longer.ConclusionsThe authors indicated to the possibility of central sensory involvement in patients with CIDP, especially based on the prolonged inter-latency of BAEPs with simultaneously confirmed root affection. The severity of central damage correlates with the degree of peripheral nerve impairment.
Highlights
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, sometimes including the central nervous system
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune disorder characterized by progressive peripheral neuropathy with antibodies directed against the myelin sheath of peripheral nerves
The combined demyelinating syndrome could be a spectrum between multiple sclerosis (MS) and CIDP or a completely separate entity [6,7,8]
Summary
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, sometimes including the central nervous system. The aim of the study was the assessment of the prevalence of central sensory impairment and its reliance on peripheral nerve damage in patients with CIDP. The classic form of CIDP shows a symmetrical distribution of motor and sensory impairment, in distal and proximal parts of all four limbs, with possible involvement of cranial nerves (III, IV, VI, VII, X, XII). Dysautonomia, such as orthostatic hypotonia, dry mucous membranes, abnormal perspiration, sphincter, and sexual dysfunction, may occur. The combined demyelinating syndrome could be a spectrum between multiple sclerosis (MS) and CIDP or a completely separate entity [6,7,8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
