Abstract
Background and aimsThe clinico-neuroradiological syndrome posterior cortical atrophy (PCA) is the cardinal ‘visual dementia’. We evaluated oculomotor function in patients with PCA.Methods20 PCA patients, 17 typical Alzheimer's disease (tAD) patients...
Highlights
Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by insidious decline in visuoperceptual, visuospatial and other posterior cortical skills and atrophy of the parietal and occipital lobes (Benson et al, 1988; Mendez et al, 2002; Tang-Wai et al, 2004; see Crutch et al, 2012 for a review)
Third we evaluated the relationship between metrics of oculomotor function and performance on tests of basic visual function and higher-order object and space perception
Biomarkers of molecular pathology were available in 10/20 PCA and 11/17 typical Alzheimer’s disease patients (Table 1)
Summary
Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by insidious decline in visuoperceptual, visuospatial and other posterior cortical skills and atrophy of the parietal and occipital lobes (Benson et al, 1988; Mendez et al, 2002; Tang-Wai et al, 2004; see Crutch et al, 2012 for a review). Impairment is widely reported on tasks of higher order perception (e.g. noncanonical object recognition, complex spatial analysis) which rely on cognitive processes associated with parietal and occipito-temporal mechanisms downstream in the visual system. More basic visual functions (e.g. edge detection, form and motion coherence) which may underpin many such downstream deficits and which are mediated largely by upstream occipital mechanisms, have been largely overlooked (cf Lehmann et al, 2011a)
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