Abstract
The fraction of murine epididymal sperm with shape abnormalities ranged from 1.0–15.0% in 14 inbred strains and hybrids studied. The effect of x-rays on this fraction was examined in mice with markedly different natural levels of abnormalities, C 57BL (9.4%) and (C 57BL×C 3H)F 1 (1.0%). Dosages of 30, 100, and 300 rad produced a significant increase in the number of abnormal forms, especially from 3–8 weeks following irradiation. The fraction of abnormal sperm at 5 weeks following graded doses of radiation from 0–300 rad increased from control values to 30%. The data for the hybrid fitted curve which increased as the sol3 2 power of the dose and which gave a doubling in abnormalities compared with control at rad. Sperm abnormalities may permit a simple quantitative assay for damage to the genetic material of the male germ line.
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