Abstract
Various types of lesions may occur in the cardiophrenic space, which is located in the most inferior aspect of the anterior mediastinum and is bordered by the heart, diaphragm, and chest wall. Abnormalities detected at radiography and CT often are due to prominent pericardial fat pads, fat-containing tumors such as lipoma, pericardial cysts, enlarged lymph nodes, diaphragmatic hernias, or anterior mediastinal masses, such as thymoma or lymphoma. Although chest radiography can hint at the correct diagnosis, such as a hernia if gas is visible within intestinal loops or a pericardial cyst if an ovoid structure is sharply demarcated and homogeneous, the imaging characteristics of these lesions often can overlap. Both benign and malignant lesions can have a similar appearance. Thus CT is valuable in the diagnosis and differentiation of cardiophrenic space lesions. This article illustrates and reviews the imaging findings and differential diagnoses of lesions that may occur in the cardiophrenic space.
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