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Abstract
The levels of serum and gastric-juice IgA, IgG, and IgM and the numbers of immunoglobulin-containing mononuclear cells in the gastric mucosa were measured in a study of gastritis. 20 patients with pernicious anaemia, 6 patients with duodenal ulceration, and 4 healthy volunteers were investigated, 15 of the 20 patients with pernicious anæmia had an atypical distribution of immunoglobulin-containing mononuclear cells in the gastric mucosa: IgA-containing cells were reduced to 10% of normal while IgG-containing cells were increased by 15%. Despite this, the levels of serum-immunoglobulins were normal. The remaining five patients had normal ratios of immunoglobulin-containing cells. The levels of gastric-juice immunoglobulins were not related to the numbers of the corresponding mononuclear cells in the gastric mucosa. It is suggested that in a proportion of patients with pernicious anaemia the reduction in the number of mononuclear cells containing IgA may be primary and predispose to gastric mucosal damage.
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