Abstract
Psoriasis is a chronic, inflammatory skin disease. Although the precise etiology of psoriasis remains unclear, gut–microbiota axis might play a role in the pathogenesis of the disease. Here we investigated whether the composition of microbiota in the intestine and skin is altered in the imiquimod (IMQ)-treated mouse model of psoriasis. Topical application of IMQ to back skin caused significant changes in the composition of microbiota in the intestine and skin of IMQ-treated mice compared to control mice. The LEfSe algorithm identified the species Staphylococcus lentus as potential skin microbial marker for IMQ group. Furthermore, there were correlations for several microbes between the intestine and skin, suggesting a role of skin–gut–microbiota in IMQ-treated mice. Levels of succinic acid and lactic acid in feces from IMQ-treated mice were significantly higher than control mice. Moreover, the predictive functional analysis of the microbiota in the intestine and skin showed that IMQ caused alterations in several KEGG pathways. In conclusion, the current data indicated that topical application with IMQ to skin alters the composition of the microbiota in the gut and skin of host. It is likely that skin–gut microbiota axis plays a role in pathogenesis of psoriasis.
Highlights
Psoriasis is a chronic, inflammatory skin disease
There are several reports showing abnormal composition of skin microbiota in patients with p soriasis[20,21,22,23,24,25]. These findings suggest that alterations in the microbiome in the intestine and on the skin might play a role in the pathogenesis of psoriasis, and that improvement of altered composition of microbiota could be a therapeutic approach for this disease[14]
The major findings of this study were as follows
Summary
Inflammatory skin disease. the precise etiology of psoriasis remains unclear, gut–microbiota axis might play a role in the pathogenesis of the disease. There were correlations for several microbes between the intestine and skin, suggesting a role of skin–gut–microbiota in IMQ-treated mice. There are several reports showing abnormal composition of skin microbiota in patients with p soriasis[20,21,22,23,24,25] These findings suggest that alterations in the microbiome in the intestine and on the skin might play a role in the pathogenesis of psoriasis, and that improvement of altered composition of microbiota could be a therapeutic approach for this disease[14]. As far as we know, there are no reports showing altered composition of microbes in the intestine and on the skin of IMQ-treated mice
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