Abstract
South African Bantu subjects with a scurvy-type skin, which appears after a prolonged hemosiderosis caused by a high dietary iron intake, were studied with the oral 2-g load of tryptophan test. A majority of the subjects excreted statistically significantly elevated levels of anthranilic acid glucuronide, acetylkynurenine, kynurenine, and hydroxykynurenine, after the 2-g load of l-tryptophan. The data suggest that tryptophan metabolism in these subjects may be inhibited at some step beyond hydroxykynurenine as a result of lowered tissue pyridine nucleotide activity or tissue enzyme poisoning by the high iron levels that are present.
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