Abnormal synchronization of functional and structural networks in schizophrenia.

Abstract

Synchronization is believed to play an important role in information processing of the brain. Mounting evidence supports the hypothesis that schizophrenia is related to impaired neural synchrony. However, most previous studies characterize brain synchronization from the perspective of temporal coordination of distributed neural activity, rather than network properties. Our aim was to investigate the network synchronization alterations in schizophrenia using publically available data. Resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) were performed in 96 schizophrenia patients and 120 healthy controls. The whole-brain functional and structural networks were constructed and analyzed using graph theoretical approaches. Inter-group differences in network synchronization were investigated. Both the binary and weighted functional networks of schizophrenia patients exhibited decreased synchronizability (increased eigenratio) than those of healthy controls. With respect to the structural binary networks, schizophrenia patients showed a trend towards excessive synchronizability (decreased eigenratio). In addition, the excessive synchronizability of the structural binary networks was associated with more severe negative symptoms in schizophrenia patients. Our findings provide novel biological evidence that schizophrenia involves a disruption of neural synchrony from the perspective of network properties.