Abnormal spatial and non-spatial cueing effects in mild cognitive impairment and Alzheimer’s disease

Abstract

Our aim was to further characterize the clinical concept of mild cognitive impairment (MCI). We examined visual attention-related processing in 12 patients with amnestic MCI, 16 healthy older adults and 16 patients with Alzheimer’s disease (AD) by measuring performance on computer-based tests of attentional disengagement, alerting ability, and inhibition of return. Unlike the healthy older controls, the patients with AD and the patients with amnestic MCI exhibited a significant detriment in both the ability to disengage attention from an incorrectly cued location and the ability to use a visual cue to produce an alerting effect. The pattern of results displayed by the MCI group indicates that patients who only appear clinically to suffer from a deficit in memory also display a deficit in specific aspects of visual attention-related processing, which closely resemble the magnitude seen in AD. The authors would like to thank the Bristol Research Into Alzheimer’s and Care of the Elderly (BRACE) Charity [Registered Charity Number 297965] for financial support. The authors would also like to thank all the participants taking part and Mr A. Hughes for statistical support.