Abstract
An incidental photopenic area in the scrotum may be found on bone scintigraphy; such a lesion can be due to a benign disease (hydrocele). In contrast, increased activity of the hemi-scrotum on bone scintigraphy may indicate a malignant lesion. A 68-year-old man with enlargement of the right scrotum was found to have increased radioactivity in the right scrotum occupying two thirds of the scrotum on an anterior bone scan. On ultrasound examination, this scrotal enlargement showed diffuse hypoechoic density in the right scrotum. The patient underwent right orchiectomy and resection of right spermatic cord; pathologic examination confirmed malignant lymphoma with hematopoietic origin. Bone scan interpretation should include observable asymmetrical soft tissue activity of the scrotum to depict scrotal abnormality
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