Abnormal renal haemodynamics during exercise in young patients with mild essential hypertension without treatment and during long-term propranolol therapy.

Abstract

The effect of exercise on renal haemodynamics was studied in young patients with mild essential hypertension: in nine untreated patients and eleven patients treated with propranolol for 19 months, and in ten normotensive healthy control subjects. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were measured during four consecutive periods: a pre-exercise control period, two periods with exercise loads of 450 kpm/min and 600 kpm/min, respectively, and a post-exercise control period. Comparison within groups showed a gradual fall in RPF and GFR during increasing exercise loading for both the untreated and propranolol-treated patients and the control subjects. Comparison between groups revealed no significant differences in RPF and GFR in the pre-exercise control period. For both intensities of exercise loading, RPF was signicantly lower in the untreated patients than in the control subjects, but higher than in the propranolol-treated patients. GFR in the untreated group did not differ from the ...