Abstract
SUMMARYObjectives: Compare resting state regional cerebral blood flow [rCBF] in patients with fibromyalgia [FMS], non-patients with FMS, and healthy controls as a function of insidious or physically traumatic symptom onset.Methods: All subjects were women and included 21 FMS patients with insidious symptom onset; 11 FMS patients with physically traumatic onset; 13 residents recruited from the Alabama community with FMS of insidious onset who had not consulted a physician for pain in the past 10 years [non-patients]; and 29 residents recruited from the Alabama community without FMS or any other chronic pain syndromes or illnesses [healthy controls]. All subjects underwent single photon emission computed tomographic imaging of brain rCBF during resting conditions, pain threshold assessment, as well as lumbar puncture, and they completed standardized self-report measures of pain intensity, fatigue, and depression. Group differences on these assessments were evaluated by analysis of variance and the Least Sig...
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