Abnormal pulse pressure and microalbuminuria in Haitian Americans with type 2 diabetes (1029.6)

Abstract

This cross sectional study examined the relationship between pulse pressure and microalbuminuria (MA) in Haitian Americans with type 2 diabetes. Subjects (n=133) were recruited from multiple sources from South Florida. Blood pressure was measured twice and averaged to calculate pulse pressure. Pulse pressure was calculated by systolic blood pressure minus diastolic blood pressure. Glycosylated hemoglobin (A1C) levels were measured from fasting blood samples with the Roche Tina‐Quant method. MA was determined in urine samples by a semiquantitative assay (ImmunoDip). Statistical analysis included t‐test, chi‐square and logistic regression, controlling for age, gender, BMI, A1C and hypertension medications. MA was present in 35% of Haitian Americans with type 2 diabetes. A significantly higher percentage of Haitian Americans with MA had abnormal pulse pressure (>60 mmHg) as compared to those without MA (P=0.005). Logistic regression analysis showed that after controlling for covariates, subjects with abnormal pulse pressure were 3.14 times more likely to have MA as compared to those with normal pulse pressure (P=0.014; 95% confidence interval [CI]: 1.25, 7.85). Findings indicated that abnormal pulse pressure increased the odds of having earliest clinical signs for diabetic nephropathy in this group of Haitian Americans.Grant Funding Source: Supported by NIH/NIDDK sponsored grant.