Abstract
The transformation of pregnenolone to progesterone and the 20α-reduction of progesterone were studied in the 10,000 × g supernatant of a homogenate of a placenta from a spontaneous abortion at 22 weeks' gestation. The results of these experiments were compared to results from similar experiments with the use of normal placentas of various gestational ages. The placenta from the spontaneous abortion exhibited a decreased ability to synthesize progesterone and an increased transformation of progesterone to 20α-hydroxy-4-pregnen-3-one, an inhibitor of progesterone synthesis.
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