Abstract
Abnormal Plasticity and Epigenesis in Epileptic Seizures of an EL Mouse
Highlights
Epilepsy is known to be a highly complicated disease or syndrome [1]
The EL mice were exposed to the natural proprioceptive sensory stimulation of tossing the animal into the air to provoke an epileptic seizure, which results from an increase in the excitability of the cortical neurons due to low activities of Glutamic acid decarboxylase (GAD) and Gamma-amino butyric acid (GABA)
The EL mouse is an established animal model of epilepsy [2], and several studies have investigated the epileptogenesis of this disease using the EL mouse model [3,4,5]
Summary
The abnormal plasticity and epigenetic phenomenon observed in the development of epileptic seizures and developmental process of an EL mouse, which is an excellent mutant model, are reviewed through the neurophysiological, biochemical and molecular aspects. The EL mice were exposed to the natural proprioceptive sensory stimulation of tossing the animal into the air to provoke an epileptic seizure, which results from an increase in the excitability of the cortical neurons due to low activities of Glutamic acid decarboxylase (GAD) and Gamma-amino butyric acid (GABA). At the same time the provoked seizures, in turn, may induce DNA fragmentation or Immediately Early Gene (IEG) expression and make some changes of neurotrophic factors and protein synthesis. These proteins or other substances may constitute another structure vulnerable to provocative stimuli to the seizure. EL mouse seizure, Natural proprioceptive sensory stimulation, Parietal cortex and hippocampus, GAD-GABA activity, Abnormal plasticity, DNA rearrangement
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