Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia.

Prune Mazer,Tiago O Paiva,Pedro Almeida,Cassilda Cunha-Reis,João Marques-Teixeira,Celeste Silveira,Fernando Barbosa,Rita Pasion,Inês Macedo,Fernando Ferreira-Santos

doi:10.3389/fpsyt.2021.630406

Prune Mazer, Tiago O Paiva + Show 8 more

Open Access

https://doi.org/10.3389/fpsyt.2021.630406

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Abstract

Auditory event-related potentials (ERP) may serve as diagnostic tools for schizophrenia and inform on the susceptibility for this condition. Particularly, the examination of N1 and P2 components of the auditory ERP may shed light on the impairments of information processing streams in schizophrenia. However, the habituation properties (i.e., decreasing amplitude with the repeated presentation of an auditory stimulus) of these components remain poorly studied compared to other auditory ERPs. Therefore, the current study used a roving paradigm to assess the modulation and habituation of N1 and P2 to simple (pure tones) and complex sounds (human voices and bird songs) in 26 first-episode patients with schizophrenia and 27 healthy participants. To explore the habituation properties of these ERPs, we measured the decrease in amplitude over a train of seven repetitions of the same stimulus (either bird songs or human voices). We observed that, for human voices, N1 and P2 amplitudes decreased linearly from stimulus 1–7, in both groups. Regarding bird songs, only the P2 component showed a decreased amplitude with stimulus presentation, exclusively in the control group. This suggests that patients did not show a fading of neural responses to repeated bird songs, reflecting abnormal habituation to this stimulus. This could reflect the inability to inhibit irrelevant or redundant information at later stages of auditory processing. In turn schizophrenia patients appear to have a preserved auditory processing of human voices.

Highlights

The orienting response to novel/rare stimuli is considered a fundamental reaction in living organisms
The habituation of the auditory N1 and P2 components of the event-related potentials (ERP) remains largely unexplored in schizophrenia, especially when compared with the body of research directed to P50 and P300 components
Our hypotheses considered the habituation properties of N1 and P2, and the different modulations induced by distinct stimulus categories

Summary

Introduction

The orienting response to novel/rare stimuli is considered a fundamental reaction in living organisms. Auditory event-related potentials (ERP) and early components such as the N1 and P2, allow tracking the time course of neural activity related to auditory processing [2] and respective habituation. Early auditory categorical differences have been reported for distinct categories of sounds (e.g., voices and bird songs) such that results suggest a rapid brain discrimination of human voices [5,6,7,8]. N1 seems to reflect a selective-orienting attention response toward novel/rare stimuli [9, 10], while P2 probably represents a subsequent stage of stimulus recognition toward specific stimuli (e.g., human voices) independently of attentional demands [5,6,7, 11]

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