Abstract
We evaluated gastric function in 8 longstanding, insulin-dependent diabetic patients with nausea and recurrent vomiting, as well as in 10 asymptomatic diabetic patients and 11 nondiabetic subjects. Gastric vagal function was assessed by measuring the gastric acid secretory response to sham feeding. Normal subjects secreted 17.2 ± 3.1 meq/hr, whereas diabetic patients with, or without, vomiting secreted 5.4 ± 1.4 and 6.4 ± 2.0 meq/hr, respectively (P From these studies we conclude that many patients with longstanding insulin-dependent diabetes have (a) reduced acid secretory responses to sham feeding, suggesting vagal neuropathy; (b) normal acid secretory responses to infused food, despite an enhanced serum gastrin response; and (c) delayed gastric emptying. These abnormalities occur both in diabetic patients with nausea and vomiting and in asymptomatic diabetic patients.
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