Abstract
Regional cortical volume asymmetry patterns, particularly those associated with language function, in 16 boys with autism (aged 7-11 years) were compared with measures in 15 normal, age- and handedness-matched controls, in an MRI study at the Massachusetts General Hospital, Boston, and other centers.
Highlights
Regional cortical volume asymmetry patterns, those associated with language function, in 16 boys with autism were compared with measures in 15 normal, age- and handedness-matched controls, in an MRI study at the Massachusetts General Hospital, Boston, and other centers
The posterior temporal fusiform gyrus was more left-sided in autism, whereas adjacent fusiform gyrus and temporooccipital inferior temporal gyrus were more right-sided in autism
Both frontal (Broca) and temporal (Wernicke) language-related association cortex regions show a reversal of assymetry in boys with autism compared to controls, but the frontal abnormality is significantly greater
Summary
ABNORMAL FRONTAL AND TEMPORAL LOBE ASYMMETRIES IN Regional cortical volume asymmetry patterns, those associated with language function, in 16 boys with autism (aged 7-11 years) were compared with measures in 15 normal, age- and handedness-matched controls, in an MRI study at the Massachusetts General Hospital, Boston, and other centers. Boys with autism had significant asymmetry reversal in frontal language-related cortex: 27% larger on the right in autism and 17% larger on the left in normal controls. The posterior temporal fusiform gyrus was more left-sided in autism, whereas adjacent fusiform gyrus and temporooccipital inferior temporal gyrus were more right-sided in autism.
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