Abnormal findings in brainstem auditory evoked response at 36–37 weeks of postconceptional age in babies with neonatal chronic lung disease

Abstract

AimTo examine brainstem auditory function at 36–37weeks of postconceptional age in preterm infants who are diagnosed to have neonatal chronic lung disease (CLD). Study designPreterm infants, born at 31 and less weeks of gestation, were studied at 36–37weeks of postconceptional age when they were diagnosed to have neonatal CLD. Brainstem auditory evoked response (BAER) was recorded and analyzed at different click rates. ResultsCompared with healthy controls at the same postconceptional age, the CLD infants showed a slightly increase in BAER wave V latency. However, the I-V, and III–V interpeak intervals in the CLD infants were significantly increased. The III–V/I–III interval ratio was also significantly increased. The amplitudes of BAER waves III and V in the CLD infants tended to be reduced. These BAER findings were similar at all 21, 51 and 91/s clicks, although the abnormalities tended to be more significant at higher than at low click rates. ConclusionAt 36–37weeks of postconceptional age, BAER was abnormal in preterm infants who were diagnosed to have neonatal CLD. This suggests that at time when the diagnosis of CLD is made there is functional impairment, reflecting poor myelination, in the brainstem auditory pathway in preterm infants with neonatal CLD.