Abstract
Steroid metabolism in three premenopausal and 28 postmenopausa l patients with endometrial cancer was investigated by determining the excretion of 14 neutral steroids in 24-hr urine specimens. When compared with 55 postmenopausal normal controls, the postmenopausal patients had depressed excretion of I 1-deoxy-17-ketosteroids and increased excretion of 1 1-ketoandrosterone. The excretion of urinary pregnanes and corticosteroids was also depressed in the patient group as compared with the control group. The deviations in urinary steroids of cancer patients were not affected by radical surgery. Evidences indicated that the steroidal abnormalities in endometrial cancer patients, as distinguished from those in patients with cancer of the breast or uterine cervix, are related to a homeostatic impairment in the metabolism of testosterone and progesterone. Epidemiological analysis showed that patients with endometrial cancer were distinguishable from the urban controls by decreased height and relative infertility, and from the rural controls by increased weight, acceleration of menarche, and relative infertility, a finding which suggests a long-lasting depression of endogenous testosterone and progesterone.
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