Abstract
AbstractIn a short series of experiments on rabbits abnormal blood‐brain passage of S35‐labelled Aprobita quaternary phenothiazine derivative) was induced by regional shortlasting perfusion of Hg2+, cyanine dye 863 or unlabelled Aprobit through cerebral vessels. Cerebral uptake of S35‐Aprobit was recorded by means of autoradiography and radioassay. In two control experiments with intact brains practically no radioactivity was found in the brain. The results are discussed with reference to the hypothesis that brain‐blood directed transport mechanisms are involved in blood‐brain barring of certain groups of organic ions.
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