Abstract
Vertical ablation, which is caused by oblique transmission geometry, was applied for high reproducible matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). In terms of desorption behavior of analytes and reproducibility of MALDI-MS measurements, comparative evaluations of this oblique transmission geometry with a reflection geometry were done in this paper. We found a large difference in laser ablation direction and amount of desorbed sample between these two irradiation techniques. This difference directs to drastic improvements of signal intensity and shot-to-shot reproducibility in mass spectra.
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