Abstract
Aim: Persistence cells comprise a subpopulation of bacteria that is resistant to treatment. In this study, the role of thetoxin-antitoxin (TA)system in the formation of persistence cells of Acinetobacter baumannii isolates was investigated. Methods: After confirming all isolates, TA systems abkBA, mqsRA and higBA were identified. Persister cells were confirmed using the standard method. Real-time PCR was used to compare the expression of TA systems in isolates in persistence and normal states. Results: The abkAB system was present in all isolates; 4% of isolates formed persister cells. The expression level of theabkB gene in persistent isolates showed a sevenfold increase compared with nonpersistent isolates. Conclusion:The abkBA system is proposed as an antipersistence target in A. baumannii isolates.
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