Abstract
Monovalent and bivalent Fab fragments from normal human and rabbit γ-globulins were shown to suppress blast transformation of human lymphocytes induced by phytohemagglutinin and concanavalin A. The pepsin F(ab')2 fragments obtained from highly purified rabbit antidinitrophenyl antibodies possess similar properties. An inhibitory action of the fragments was observed when they were added to the culture both simultaneously with and 24 and 48 h after the mitogen. The results may mean that suppression of lymphocyte transformation by fragments of γ-globulins is not due to their composition with the mitogens for receptors on the target cells; activity of the Fab fragment is evidently determined by structures located outside the combining site of the antibody.
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