Abstract
Anti-brain heteroantisera prepared in rabbits against mouse and dog brain tissues appear to distinguish T from B lymphocytes in homologous species, although some sensitivity of bone marrow cells to these antisera is also observed. Cross-reactivity of these antisera with heterologous thymus cells could not be demonstrated. The brain T lymphocyte antigen (BAθ) could not be detected in fetal mouse brain and was only present in neonatal dog brain in low concentration, increasing in concentration in a sigmoidal fashion with maturation. Rabbit antisera to human brain tissue (frontal lobe) did not have corresponding specificity for human thymus cells. Anti-mouse brain antisera are not immunosuppressive in allografted mice.
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