Abstract
Experiments on AKR and C57BL mice of different ages, using experimental models of transplantable Gross (first generation), Pujman, and spontaneous leukemia of AKR mice, showed that the ability of mice to produce humoral antibodies is inversely proportional to their susceptibility to inoculation of syngeneic leukemic cells and also to the incidence of spontaneous leukemia. The difference in ability to form an immune response to heterologous antigen were due to the physiological processes taking place in the aging organism. The results indicate that a failure of one component of immunity does not necessarily lead to an increased risk of tumor development in vivo.
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