Ability of α – II Spectrin Breakdown Products and Septin 5 as Predictors for Severity and Clinical Outcome in Rheumatoid Arthritis Patients

Abstract

There is a continuous interesting in finding new biomarkers that can be used as diagnostic tools for severity of rheumatoid arthritis (RA). Septin-5, a protein that indirectly inhibit neurotransmitter release, Alpha-2 spectrin breakdown products 145 (SBDP145), a protein that increased in neuronal damage, and vitamin D (VitD) are measured in the sera of 120 RA patients and 60 healthy controls (HC). The results showed an increase in SBDP145 level and a decrease in the VitD and calcium levels in RA group compared to HC. While no significant difference in septin-5 and magnesium between the groups. The receiver operating characteristics study showed that VitD has a good sensitivity and specificity for differentiating RA from HC. While Septin-5 and SBDP145 have no significant sensitivity and specificity. There is an increase in the serum levels of erythrocyte sedimentation rate (ESR) and anticyclic citrullinated protein antibody (ACCPA) in RA patients compared with the control group. Also, there are high ratios of RA patients with positive results of C-reactive protein (CRP) and rheumatoid factor (RF). It can be concluded that RA patients are suffering from hypovitaminosis D and hypocalcemia.