Abstract
Summary form only given. Multiphoton confocal microscopy with extremely short (10 fs) optical pulses requires reflective optics, and ultimately requires control of the spatial wavefront in order to achieve diffraction-limited performance. We have demonstrated the use of a deformable mirror to adaptively optimize the focusing of a 10-fs pulse in an imaging geometry. We optimize the second harmonic generation or two-photon fluorescence signal from our sample using a feedback loop based on a genetic algorithm. To improve the speed of the convergence of our algorithm we use a Zernike orthogonal basis to control the deformable mirror.
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