Abstract
The dysregulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has been implicated in diabetes mellitus. However, the role of PGC-1α in diabetic nephropathy (DN) is still inconclusive. Our aim was to evaluate the renal expression of PGC-1α and its regulators: silent information regulator 2 homolog (Sirt-1) and glycogen synthase kinase3β (GSK3β) in the diabetic rats. Nineteen adult male rats were randomly divided into the control group (n = 6) and the diabetic group (n = 13). The expression of these genes was performed by quantitative real-time PCR (qRT-PCR) in the renal tissues. Also, catalase activity was measured by a colorimetric method. The diabetic rats had higher expression levels of PGC-1α and GSK3β; however, the expression of Sirt-1 and catalase activity was significantly lower in comparison to the control group (p < 0.05). We concluded that the aberrant expression of PGC-1α, Sirt-1, and GSK3β may be associated with the developing of DN.
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