Aberrant receptor expression in primary aldosteronism

Abstract

Objectives: In adrenal Cushing's syndrome aberrant hormone receptor expression is involved in hormone excess in a subset of patients. Especially in massive ACTH independent makronodular adrenal hyperplasia nearly 100% of the adrenal lesions expresses aberrant hormone receptors. The molecular cause of primary aldosteronism is poorly understood. Therefore, we aimed to investigate the expression of aberrant hormone receptors in individuals with primary aldosteronism of various origin.