Abstract
This chapter discusses the fundamentals of porous silicon (PSi) based DNA biosensors. Various surface functionalization approaches are introduced, including surface passivation techniques that can be used to prevent corrosion of the PSi matrix upon DNA hybridization. Several PSi DNA sensor configurations are presented, ranging from single-layer interferometers to on-chip ring resonators, with a focus on performance in terms of sensitivity and limit of detection. Challenges to real-world implementation of PSi DNA biosensors are addressed and important areas of progress in on-chip integration and incorporation of microfluidic channels are highlighted. The chapter ends with an outlook on future point-of-care diagnostic applications.
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