Abstract
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and their preventions and treatments, etc.
Highlights
Alternative splicing is a highly regulated process that plays a critical role in diversification of the transcriptome and proteome in the cell
Expression of splicing factor Esrp2 is increased in the adult liver as this splicing factor plays an important role in mesenchymal to epithelial transformation (MET) that is the opposite of epithelial to mesenchymal transformation (EMT), observed in cancer tissues
The findings reviewed here, though handful, are sufficient to show that the Alternative splicing (AS) plays a very critical role in regulating hepatocellular carcinoma (HCC) progression and diagnostic
Summary
Alternative splicing is a highly regulated process that plays a critical role in diversification of the transcriptome and proteome in the cell. Genome-wide studies showed that most multi-exon genes in human undergo alternative splicing and produce multiple mRNA isoforms from a single pre-mRNA in a tissue or developmental stage-specific manner[6,7]. Different cis-regulatory elements in the pre-mRNA play a critical role in alternative selection of splice sites by binding to splicing regulatory proteins.
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