Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia

Yang Yang,Seisho Takeuchi,Wolf K Hofmann,Takayuki Ikezoe,Jacques J.M Van Dongen,Tomasz Szczepański,Claus R Bartram,Norihide Yoshino,Hirokuni Taguchi,H Phillip Koeffler

doi:10.1016/j.leukres.2005.06.002

Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia

Yang Yang, Seisho Takeuchi + Show 8 more

https://doi.org/10.1016/j.leukres.2005.06.002

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Journal: Leukemia Research	Publication Date: Jul 21, 2005
Citations: 35

Affiliation: Kōchi University, Charité - Universitätsmedizin Berlin, Erasmus University Rotterdam, Heidelberg University, Cedars-Sinai Medical Center

#Adult Acute Lymphoblastic Leukemia #Acute Lymphoblastic Leukemia + Show 8 more

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Abstract

Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARβ, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARβ was more frequent in adult ALL than that in childhood ALL ( p = 0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL ( p = 0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL ( p = 0.01).

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